Reactome | Complex I biogenesis

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Complex I biogenesis Show undefined attributes

authored	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
created	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
dbId	6799198
displayName	Complex I biogenesis
edited	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
eventOf	[Pathway:R-HSA-611105] Respiratory electron transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262397] mitochondrial respiratory chain complex I assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5690023] NUBPL binds 4Fe-4S - Homo sapiens [BlackBoxEvent:R-HSA-6788523] NUBPL transfers 4Fe-4S to Complex I subunits - Homo sapiens [BlackBoxEvent:R-HSA-6788556] NUBPL transfers 4Fe-4S to NDUFV1, V2 - Homo sapiens [Reaction:R-HSA-6800868] NDUF subunits bind to form the IP subcomplex - Homo sapiens [Reaction:R-HSA-6799203] IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 - Homo sapiens [Reaction:R-HSA-6799178] Intermediate 1 binds HP subcomplex to form Intermediate 2 - Homo sapiens [Reaction:R-HSA-6799191] Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex - Homo sapiens [Reaction:R-HSA-6799199] COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex - Homo sapiens [Reaction:R-HSA-6799202] The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex - Homo sapiens [Reaction:R-HSA-6799197] ND4, ND5 bind the 550kDa complex to form the 815kDa complex - Homo sapiens [Reaction:R-HSA-6800870] NDUF subunits bind to form the FP subcomplex - Homo sapiens [Reaction:R-HSA-6799179] Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex - Homo sapiens [Reaction:R-HSA-6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5689024] Assembly factors for the membrane arm of human complex I [LiteratureReference:5689694] Assembly factors of human mitochondrial complex I and their defects in disease [LiteratureReference:5334675] Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process [LiteratureReference:6788511] Understanding mitochondrial complex I assembly in health and disease
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	Complex I biogenesis
orthologousEvent	[Pathway:R-DDI-6799198] Complex I biogenesis - Dictyostelium discoideum [Pathway:R-CEL-6799198] Complex I biogenesis - Caenorhabditis elegans [Pathway:R-DME-6799198] Complex I biogenesis - Drosophila melanogaster [Pathway:R-GGA-6799198] Complex I biogenesis - Gallus gallus [Pathway:R-XTR-6799198] Complex I biogenesis - Xenopus tropicalis [Pathway:R-DRE-6799198] Complex I biogenesis - Danio rerio [Pathway:R-SSC-6799198] Complex I biogenesis - Sus scrofa [Pathway:R-BTA-6799198] Complex I biogenesis - Bos taurus [Pathway:R-CFA-6799198] Complex I biogenesis - Canis familiaris [Pathway:R-RNO-6799198] Complex I biogenesis - Rattus norvegicus [Pathway:R-MMU-6799198] Complex I biogenesis - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6801257] Meldal, Birgit, 2015-10-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6799198
summation	[Summation:5689695] Complex I (NADH:ubiquinone oxidoreductase or NADH dehydrogen...

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(hasEvent)

[Pathway:R-HSA-611105] Respiratory electron transport

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