Reactome | Mitochondrial iron-sulfur cluster biogenesis

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Mitochondrial iron-sulfur cluster biogenesis Show undefined attributes

compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649472
displayName	Mitochondrial iron-sulfur cluster biogenesis
eventOf	[TopLevelPathway:R-DRE-1430728] Metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24332] iron-sulfur cluster assembly
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-1362416] Frataxin binds iron - Danio rerio [Pathway:R-DRE-2395516] Electron transport from NADPH to Ferredoxin - Danio rerio [BlackBoxEvent:R-DRE-1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster - Danio rerio
inferredFrom	[Pathway:R-HSA-1362409] Mitochondrial iron-sulfur cluster biogenesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Mitochondrial iron-sulfur cluster biogenesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-1362409
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-DRE-1430728] Metabolism
(hasEncapsulatedEvent)	[Pathway:R-DRE-9865881] Complex III assembly [Pathway:R-DRE-6799198] Complex I biogenesis [Pathway:R-DRE-9854311] Maturation of TCA enzymes and regulation of TCA cycle [Pathway:R-DRE-9857492] Protein lipoylation
(inferredTo)	[Pathway:R-HSA-1362409] Mitochondrial iron-sulfur cluster biogenesis

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