CSN2 gene expression is stimulated by ERBB4s80:STAT5A

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Reaction [omitted]
Homo sapiens
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ERBB4s80:STAT5A complex binds to and stimulates transcription from the beta-casein (CSN2) promoter, and it probably regulates transcription of other lactation-related genes in mammary cells. By over-expressing either human ERBB4cyt1s80 or ERBB4cyt2s80 in mouse mammary cell line HC11 or transgenic mice, Muraoka-Cook et al. showed differential effects of CYT1 and CYT2 isoforms on mammary epithelium. CYT1s80 over-expression decreases cell proliferation, promotes STAT5A-mediated transcription of beta-casein (CSN2) and lactogenic differentiation. In contrast, CYT2s80 over-expression causes epithelial hyperplasia, increased levels of Wnt and beta-catenin, as well as elevated expression of c-myc and cyclin D1 (Muraoka-Cook et al. 2009).

Literature References
PubMed ID Title Journal Year
15534001 The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

Vidal, GA, Beckman, BS, Marrero, L, Jones, FE, Williams, CC, Burow, ME, Allison, JG

J Cell Biol 2004
18653779 Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation

Earp HS, 3rd, Muraoka-Cook, RS, Hunter, D, Miraglia, L, Sandahl, MA

Mol Endocrinol 2008
19596786 ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo

Earp HS, 3rd, Hunter, DM, Muraoka-Cook, RS, Miraglia, LC, Chodosh, LA, Strunk, KE, Husted, C, Sandahl, MA, Elenius, K

Mol Cell Biol 2009
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