Reactome | Ligand-independent dimerization of EGFRvIII mutant

Ligand-independent dimerization of EGFRvIII mutant

Stable Identifier

R-HSA-1248002

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Ligand-independent dimerization of EGFRvIII mutant

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands, but is able to dimerize spontaneously. Self-dimerization may be dependent on N-linked glycosylation.

Literature References

PubMed ID	Title	Journal	Year
11087732	Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells Cohen, S, Fernandes, H, Bishayee, S	J Biol Chem	2001

Participants

Input

x 2 EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)

Output

EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)

Participates

as an event of

Constitutive Signaling by EGFRvIII (Homo sapiens)

Functional status

Gain of function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Disease Entity

Status

gain of function via inframe deletion

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Authored

Orlic-Milacic, M (2011-11-04)

Reviewed

Greulich, H (2011-11-15)

Savas, S (2011-11-15)

Created

Orlic-Milacic, M (2011-04-09)

Cite Us!