Ligand-independent dimerization of EGFRvIII mutant

Stable Identifier
R-HSA-1248002
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands, but is able to dimerize spontaneously. Self-dimerization may be dependent on N-linked glycosylation.

Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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