Reactome | Ligand-independent dimerization of EGFRvIII mutant

Ligand-independent dimerization of EGFRvIII mutant

Stable Identifier

R-HSA-1248002

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Ligand-independent dimerization of EGFRvIII mutant

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EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands, but is able to dimerize spontaneously. Self-dimerization may be dependent on N-linked glycosylation.

Literature References

PubMed ID	Title	Journal	Year
11087732	Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells Fernandes, H, Cohen, S, Bishayee, S	J Biol Chem	2001

Participants

Input

x 2 EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)

Output

EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)

Participates

as an event of

Constitutive Signaling by EGFRvIII (Homo sapiens)

Functional status

Gain of function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Disease Entity

Status

gain of function via inframe deletion

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

Mondo

0004992

Authored

Orlic-Milacic, M (2011-11-04)

Reviewed

Greulich, H (2011-11-15)

Savas, S (2011-11-15)

Created

Orlic-Milacic, M (2011-04-09)

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