Reactome | SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-

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SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- Show undefined attributes

authored	[InstanceEdit:1237008] May, B, 2011-03-24
catalystActivity	[CatalystActivity:1237040] solute:inorganic anion antiporter activity of SLC4A1 dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1237041] May, B, 2011-03-30
crossReference	[DatabaseIdentifier:12668049] RHEA:72363
dbId	1237038
diseaseReaction	[FailedReaction:R-HSA-5656248] Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) - Homo sapiens
displayName	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-
edited	[InstanceEdit:1237008] May, B, 2011-03-24
eventOf	[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Homo sapiens
followingEvent	[Reaction:R-HSA-1237059] CA4:Zn2+ dehydrates HCO3- to CO2 - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-111627] HCO3- [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1237464] A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers [LiteratureReference:1237501] Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer [LiteratureReference:1237494] The asymmetry of chloride transport at 38 degrees C in human red blood cell membranes
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic bicarbonate for extracellular chloride
orthologousEvent	[Reaction:R-CEL-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Caenorhabditis elegans [Reaction:R-DME-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Drosophila melanogaster [Reaction:R-GGA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Gallus gallus [Reaction:R-XTR-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Xenopus tropicalis [Reaction:R-DRE-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Danio rerio [Reaction:R-SSC-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Sus scrofa [Reaction:R-BTA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Bos taurus [Reaction:R-CFA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Canis familiaris [Reaction:R-RNO-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Rattus norvegicus [Reaction:R-MMU-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Mus musculus
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-425425] HCO3- [extracellular region]
precedingEvent	[Reaction:R-HSA-1475435] CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- - Homo sapiens
releaseDate	2012-06-12
reverseReaction	[Reaction:R-HSA-1247665] SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2207684] Jassal, B, 2012-04-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1237038
summation	[Summation:1244358] The band 3 anion exchange protein (AE1, SLC4A1) exchanges ch...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5656248] Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes)
(hasEvent)	[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen
(precedingEvent)	[Reaction:R-HSA-1237059] CA4:Zn2+ dehydrates HCO3- to CO2