Reactome | SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-

Schema > Reaction > Entries

SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- Show undefined attributes

catalystActivity	[CatalystActivity:10594183] solute:inorganic anion antiporter activity of SLC4A1 dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10594185
displayName	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-
eventOf	[Pathway:R-DRE-1237044] Erythrocytes take up carbon dioxide and release oxygen - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-1237059] CA4:Zn2+ dehydrates HCO3- to CO2 - Danio rerio
inferredFrom	[Reaction:R-HSA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-111627] HCO3- [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic bicarbonate for extracellular chloride
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-425425] HCO3- [extracellular region]
precedingEvent	[Reaction:R-DRE-1475435] CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1237038
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1237044] Erythrocytes take up carbon dioxide and release oxygen
(precedingEvent)	[Reaction:R-DRE-1237059] CA4:Zn2+ dehydrates HCO3- to CO2
(inferredTo)	[Reaction:R-HSA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-

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