SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-

Stable Identifier
Reaction [transition]
Homo sapiens
Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic bicarbonate for extracellular chloride
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The band 3 anion exchange protein (AE1, SLC4A1) exchanges chloride (Cl-) for bicarbonate (HCO3-) across the plasma membrane according to the concentration gradients of the anions (Knauf et al. 1996, Dahl et al. 2003). SLC4A1 may be part of a complex ("metabolon") with carbonic anhydrase II (CA2) which would facilitate the transport of HCO3- (Sterling et al. 2001).

Literature References
PubMed ID Title Journal Year
12933803 Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer

Stuart-Tilley, AK, Alper, SL, Shmukler, BE, Jiang, L, Chernova, MN, Dahl, NK

J Biol Chem 2003
11606574 A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers

Sterling, D, Reithmeier, RA, Casey, JR

J Biol Chem 2001
8972395 The asymmetry of chloride transport at 38 degrees C in human red blood cell membranes

Gasbjerg, PK, Brahm, J, Knauf, PA

J Gen Physiol 1996
Catalyst Activity

inorganic anion exchanger activity of SLC4A1 dimer [plasma membrane]

Orthologous Events
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