Reactome | Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha

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Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha Show undefined attributes

authored	[InstanceEdit:1234160] May, B, 2011-03-09
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1234178] May, B, 2011-03-18
dbId	1234183
displayName	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
edited	[InstanceEdit:1234160] May, B, 2011-03-09
eventOf	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Homo sapiens
followingEvent	[Reaction:R-HSA-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Homo sapiens
input	[DefinedSet:R-HSA-1234106] hydroxyPro-HIF-alpha [cytosol] [Complex:R-HSA-8932458] PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1234028] Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein [LiteratureReference:392095] Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein [LiteratureReference:1234072] Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein [LiteratureReference:392092] Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation [LiteratureReference:1233947] HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing [LiteratureReference:1234023] Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein [LiteratureReference:1234037] HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation [LiteratureReference:1234014] Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm [LiteratureReference:1233957] Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein [LiteratureReference:8932475] The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
orthologousEvent	[Reaction:R-MMU-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Mus musculus [Reaction:R-CEL-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Caenorhabditis elegans [Reaction:R-DME-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Drosophila melanogaster [Reaction:R-GGA-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Gallus gallus [Reaction:R-XTR-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Xenopus tropicalis [Reaction:R-SSC-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Sus scrofa [Reaction:R-BTA-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Bos taurus [Reaction:R-CFA-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Canis familiaris [Reaction:R-RNO-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Rattus norvegicus
output	[Complex:R-HSA-1234125] hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol]
precedingEvent	[Reaction:R-HSA-1234179] Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) - Homo sapiens [Reaction:R-HSA-1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A - Homo sapiens [Reaction:R-HSA-1234173] Cytosolic PHD2,3 hydroxylates proline residues on HIF3A - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1234183
summation	[Summation:1235014] VHL within the VHL:ElonginB:ElonginC:CUL2:RBX1 Complex binds...
updateTrackers	[UpdateTracker:9782786] Update Tracker - [Reaction:1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - v58:[addLiteratureReference, add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9782786] Update Tracker - [Reaction:1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - v58:[addLiteratureReference, add_removeInput]
(hasEvent)	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
(precedingEvent)	[Reaction:R-HSA-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha

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