Reactome | Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha

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Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha Show undefined attributes

authored	[InstanceEdit:1234160] May, B, 2011-03-09
catalystActivity	[CatalystActivity:1234182] ubiquitin-protein transferase activity of hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1234178] May, B, 2011-03-18
dbId	1234163
displayName	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
edited	[InstanceEdit:1234160] May, B, 2011-03-09
eventOf	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1234159] Proteasome proteolyzes ub-HIF-alpha - Homo sapiens
input	[Complex:R-HSA-1234125] hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] [Complex:R-HSA-1234116] UBE2D1,2,3:Ubiquitin [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:392077] Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex [LiteratureReference:1233950] Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex [LiteratureReference:1234031] Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex [LiteratureReference:1233955] Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein [LiteratureReference:392095] Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein [LiteratureReference:1234014] Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm [LiteratureReference:1233961] Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein [LiteratureReference:8932475] The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
orthologousEvent	[Reaction:R-MMU-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Mus musculus [Reaction:R-CEL-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Caenorhabditis elegans [Reaction:R-DME-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Drosophila melanogaster [Reaction:R-GGA-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Gallus gallus [Reaction:R-DRE-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Danio rerio [Reaction:R-SSC-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Sus scrofa [Reaction:R-BTA-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Bos taurus [Reaction:R-CFA-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Canis familiaris [Reaction:R-RNO-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Rattus norvegicus
output	[Complex:R-HSA-8932472] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] [DefinedSet:R-HSA-1234120] UBE2D1,2,3 [cytosol]
precedingEvent	[Reaction:R-HSA-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1234163
summation	[Summation:1235021] VHL is an E3 ubiquitin ligase that conjugates ubiquitin to h...
updateTrackers	[UpdateTracker:9782920] Update Tracker - [Reaction:1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - v58:[addLiteratureReference, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9782920] Update Tracker - [Reaction:1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - v58:[addLiteratureReference, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
(precedingEvent)	[BlackBoxEvent:R-HSA-1234159] Proteasome proteolyzes ub-HIF-alpha

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