Reactome | EGFR L747_T751delinsP [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

EGFR L747_T751delinsP [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228014] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:1655506] COSMIC:COSM24573 [DatabaseIdentifier:1655507] COSMIC:COSV51765856 [DatabaseIdentifier:1655510] COSMIC:COSV51803491
dbId	1228012
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500689] cancer [Disease:1500699] lung cancer
displayName	EGFR L747_T751delinsP [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[FragmentReplacedModification:9628407] Replacement of residues 747 to 751 by P
inDisease	true
literatureReference	[LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
maxDepth	1
modified	[InstanceEdit:9628406] Orlic-Milacic, Marija, 2018-11-08
name	EGFR L747_T751delinsP Epidermal Growth Factor Receptor L747_T751delinsP EGFR Leu747_Thr751delinsPro EGFR L747_T751>P
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1228012
startCoordinate	25
updateTrackers	[UpdateTracker:9899886] Update Tracker - [EntityWithAccessionedSequence:1228012] EGFR L747_T751delinsP [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9887853] Update Tracker - [EntityWithAccessionedSequence:1228012] EGFR L747_T751delinsP [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9899886] Update Tracker - [EntityWithAccessionedSequence:1228012] EGFR L747_T751delinsP [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9887853] Update Tracker - [EntityWithAccessionedSequence:1228012] EGFR L747_T751delinsP [plasma membrane] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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