Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants

Stable Identifier
R-HSA-1225952
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
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Constitutive phosphorylation of SHC1 was directly demonstrated in cells expressing EGFR L858R mutant (Greulich et al. 2005). Other EGFR cancer mutants were not directly tested for their ability to phosphorylate SHC1, but are assumed to interact with SHC1 in the same way as the wild-type EGFR protein.
Literature References
PubMed ID Title Journal Year
16187797 Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

Feng, WL, Hahn, WC, Chen, TH, Meyerson, M, Frank, DA, Sellers, WR, Jänne, PA, Alvarez, JV, Greulich, H, Bulmer, SE, Zappaterra, M

PLoS Med 2005
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]

Physical Entity
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)
Functional status

Gain of function of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-03-03)
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