Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants

Stable Identifier
R-HSA-1225952
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Constitutive phosphorylation of SHC1 was directly demonstrated in cells expressing EGFR L858R mutant (Greulich et al. 2005). Other EGFR cancer mutants were not directly tested for their ability to phosphorylate SHC1, but are assumed to interact with SHC1 in the same way as the wild-type EGFR protein.

Literature References
PubMed ID Title Journal Year
16187797 Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

Greulich, H, Chen, TH, Feng, WL, Jänne, PA, Alvarez, JV, Zappaterra, M, Bulmer, SE, Frank, DA, Hahn, WC, Sellers, WR, Meyerson, M

PLoS Med 2005
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]

Normal reaction
Functional status

Gain of function of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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