Peroxynitrite is reduced to nitrite by Tpx

Stable Identifier
R-HSA-1222755
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Peroxynitrite is reduced to nitrite by Tpx
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Tpx, like AhpC, is a peroxiredoxin with alkylhydroperoxidase, peroxidase, and peroxynitritase activities. Peroxynitrite is detoxified to nitrite (Jaeger et al. 2006, Rho et al. 2006).

Literature References
PubMed ID Title Journal Year
16884737 Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis

Pédelacq, JD, Terwilliger, TC, Hung, LW, Rho, BS, Vigil, D, Park, MS, Holton, JM, Kim, SI

J Mol Biol 2006
14871480 Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis

Singh, M, Flohé, L, Radi, R, Budde, H, Jaeger, T, Trujillo, M, Menge, U

Arch Biochem Biophys 2004
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Catalyst Activity

peroxiredoxin activity of Tpx dimer [cytosol]

Physical Entity
Tpx dimer [cytosol] (Mycobacterium tuberculosis)
Activity
peroxiredoxin activity (GO:0051920)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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