Peroxynitrite is reduced to nitrite by Tpx

Stable Identifier
R-HSA-1222755
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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General
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Tpx, like AhpC, is a peroxiredoxin with alkylhydroperoxidase, peroxidase, and peroxynitritase activities. Peroxynitrite is detoxified to nitrite (Jaeger et al. 2006, Rho et al. 2006).

Literature References
PubMed ID Title Journal Year
14871480 Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis

Jaeger, T, Budde, H, Flohé, L, Menge, U, Singh, M, Trujillo, M, Radi, R

Arch Biochem Biophys 2004
16884737 Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis

Rho, BS, Hung, LW, Holton, JM, Vigil, D, Kim, SI, Park, MS, Terwilliger, TC, Pédelacq, JD

J Mol Biol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peroxiredoxin activity of Tpx dimer [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created