Reactome | NOX2 generates superoxide from oxygen

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NOX2 generates superoxide from oxygen Show undefined attributes

authored	[InstanceEdit:1222281] Stephan, R, 2011-01-10
catalystActivity	[CatalystActivity:1222383] superoxide-generating NAD(P)H oxidase activity of NOX2 complex [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:1222482] Jassal, B, 2011-02-28
crossReference	[DatabaseIdentifier:12667843] RHEA:63181
dbId	1222376
displayName	NOX2 generates superoxide from oxygen
edited	[InstanceEdit:1222482] Jassal, B, 2011-02-28
eventOf	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
followingEvent	[Reaction:R-HSA-1222407] Superoxide and nitric oxide react to peroxynitrite - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1222582] NADPH oxidase: an update [LiteratureReference:1222327] Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NOX2 generates superoxide from oxygen
orthologousEvent	[Reaction:R-GGA-1222376] NOX2 generates superoxide from oxygen - Gallus gallus [Reaction:R-XTR-1222376] NOX2 generates superoxide from oxygen - Xenopus tropicalis [Reaction:R-DRE-1222376] NOX2 generates superoxide from oxygen - Danio rerio [Reaction:R-SSC-1222376] NOX2 generates superoxide from oxygen - Sus scrofa [Reaction:R-BTA-1222376] NOX2 generates superoxide from oxygen - Bos taurus [Reaction:R-CFA-1222376] NOX2 generates superoxide from oxygen - Canis familiaris [Reaction:R-RNO-1222376] NOX2 generates superoxide from oxygen - Rattus norvegicus [Reaction:R-MMU-1222376] NOX2 generates superoxide from oxygen - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-1222424] O2.- [cytosol]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2213261] Warner, D, 2012-04-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1222376
summation	[Summation:1222373] Macrophage NOX2 is a membrane complex that generates superox...

Referrals

(hasEvent)	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species
(precedingEvent)	[Reaction:R-HSA-1222407] Superoxide and nitric oxide react to peroxynitrite