NOX2 generates superoxide from oxygen

Stable Identifier
R-HSA-1222376
Type
Reaction
Species
Homo sapiens
Compartment
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Macrophage NOX2 is a membrane complex that generates superoxide anions by reduction of oxygen with NADPH (Babior 1999, Dinauer et al. 1991).

Literature References
PubMed ID Title Journal Year
1763037 Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease

Dinauer, MC, Muhlebach, TJ, Erickson, RW, Seger, RA, Curnutte, JT, Messner, H, Pierce, EA, Orkin, SH

Proc Natl Acad Sci U S A 1991
10029572 NADPH oxidase: an update

Babior, BM

Blood 1999
Participants
Participates
Catalyst Activity

superoxide-generating NAD(P)H oxidase activity of NOX2 complex [phagocytic vesicle membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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