NOX2 generates superoxide from oxygen

Stable Identifier
R-HSA-1222376
Type
Reaction
Species
Homo sapiens
Compartment
phagocytic vesicle membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NOX2 generates superoxide from oxygen
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Macrophage NOX2 is a membrane complex that generates superoxide anions by reduction of oxygen with NADPH (Babior 1999, Dinauer et al. 1991).

Literature References
PubMed ID Title Journal Year
1763037 Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease

Dinauer, MC, Muhlebach, TJ, Erickson, RW, Seger, RA, Curnutte, JT, Messner, H, Pierce, EA, Orkin, SH

Proc Natl Acad Sci U S A 1991
10029572 NADPH oxidase: an update

Babior, BM

Blood 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

superoxide-generating NAD(P)H oxidase activity of NOX2 complex [phagocytic vesicle membrane]

Physical Entity
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
Activity
superoxide-generating NAD(P)H oxidase activity (GO:0016175)
Orthologous Events
NOX2 generates superoxide from oxygen (Bos taurus)
NOX2 generates superoxide from oxygen (Canis familiaris)
NOX2 generates superoxide from oxygen (Danio rerio)
NOX2 generates superoxide from oxygen (Gallus gallus)
NOX2 generates superoxide from oxygen (Mus musculus)
NOX2 generates superoxide from oxygen (Rattus norvegicus)
NOX2 generates superoxide from oxygen (Sus scrofa)
NOX2 generates superoxide from oxygen (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
Cite Us!