Reactome | NOX2 generates superoxide from oxygen

NOX2 generates superoxide from oxygen

Stable Identifier

R-HSA-1222376

Type

Reaction [transition]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane, cytosol

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Macrophage NOX2 is a membrane complex that generates superoxide anions by reduction of oxygen with NADPH (Babior 1999, Dinauer et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
10029572	NADPH oxidase: an update Babior, BM	Blood	1999
1763037	Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease Dinauer, MC, Pierce, EA, Erickson, RW, Muhlebach, TJ, Messner, H, Orkin, SH, Seger, RA, Curnutte, JT	Proc Natl Acad Sci U S A	1991