Reactome | NOX2 generates superoxide from oxygen

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NOX2 generates superoxide from oxygen Show undefined attributes

catalystActivity	[CatalystActivity:10769067] superoxide-generating NAD(P)H oxidase activity of NOX2 complex [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10769069
displayName	NOX2 generates superoxide from oxygen
eventOf	[Pathway:R-GGA-3299685] Detoxification of Reactive Oxygen Species - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1222376] NOX2 generates superoxide from oxygen - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NOX2 generates superoxide from oxygen
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-1222424] O2.- [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1222376
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-3299685] Detoxification of Reactive Oxygen Species
(inferredTo)	[Reaction:R-HSA-1222376] NOX2 generates superoxide from oxygen

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