EGF-induced dimerization of ligand-responsive EGFR mutants

Stable Identifier
R-HSA-1220613
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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EGF-induced dimerization of ligand-responsive EGFR mutants
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Although ligand-responsive EGFR mutants dimerize spontaneously, dimerization is increased in the presence of EGF.
Literature References
PubMed ID Title Journal Year
16187797 Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

Greulich, H, Chen, TH, Feng, WL, Jänne, PA, Alvarez, JV, Zappaterra, M, Bulmer, SE, Frank, DA, Hahn, WC, Sellers, WR, Meyerson, M

PLoS Med 2005
17349580 Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity

Yun, CH, Boggon, TJ, Li, Y, Woo, MS, Greulich, H, Meyerson, M, Eck, MJ

Cancer Cell 2007
19560417 The juxtamembrane region of the EGF receptor functions as an activation domain

Red Brewer, M, Choi, SH, Alvarado, D, Moravcevic, K, Pozzi, A, Lemmon, MA, Carpenter, G

Mol Cell 2009
16777603 An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

Zhang, X, Gureasko, J, Shen, K, Cole, PA, Kuriyan, J

Cell 2006
Participants
Input
Output
Participates
as an event of
Normal reaction
EGFR dimerization (Homo sapiens)
Functional status

Gain of function of EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-02-23)
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