Reactome | Resistant ligand-responsive EGFR mutants [plasma membrane]

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Resistant ligand-responsive EGFR mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-1220579] Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors - Homo sapiens
created	[InstanceEdit:1220584] Orlic-Milacic, Marija, 2011-02-22
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1220585
disease	[Disease:1500689] cancer
displayName	Resistant ligand-responsive EGFR mutants [plasma membrane]
hasMember	[Complex:R-HSA-1220574] Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] - Homo sapiens [Complex:R-HSA-1220575] Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	5
modified	[InstanceEdit:2448610] Orlic-Milacic, M, 2012-08-13
name	Resistant ligand-responsive EGFR mutants
producedByEvent	[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1220585
updateTrackers	[UpdateTracker:9873003] Update Tracker - [DefinedSet:1220585] Resistant ligand-responsive EGFR mutants [plasma membrane] - v42:[removeCompartment] [UpdateTracker:9872619] Update Tracker - [DefinedSet:1220585] Resistant ligand-responsive EGFR mutants [plasma membrane] - v41:[updateContainedMemberOrCandidate]

Referrals

(updatedInstance)	[UpdateTracker:9873003] Update Tracker - [DefinedSet:1220585] Resistant ligand-responsive EGFR mutants [plasma membrane] - v42:[removeCompartment] [UpdateTracker:9872619] Update Tracker - [DefinedSet:1220585] Resistant ligand-responsive EGFR mutants [plasma membrane] - v41:[updateContainedMemberOrCandidate]
(hasComponent)	[Complex:R-HSA-1220579] Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane]
(input)	[Reaction:R-HSA-1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors
(output)	[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants

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