Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

Stable Identifier
R-HSA-1176059
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
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Influenza A virus nonstructural protein 1 (NS1A) is a multifunctional protein that exists as a dimer and is involved in the inhibition of host cell antiviral pre-mRNA processing and counteracts host cell antiviral responses. Unlike most other RNA viruses, influenza viruses replicate in the nucleus of the host cells. NS1A protein carries two nuclear localization signal (NLS) elements and these sequence elements are recognized by importin-alpha/beta. In the cytoplasm NS1A binds to importin-alpha/beta and these protein complexes are then translocated into the nucleus through the nuclear pore complex (NPC). Note:Reactions directly involving interactions of human host proteins with foreign ones are highlighted in red.
Literature References
PubMed ID Title Journal Year
17376915 Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes

Melén, K, Kinnunen, L, Fagerlund, R, Ikonen, N, Twu, KY, Krug, RM, Julkunen, I

J Virol 2007
15702989 An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein

Cros, JF, Garcia-Sastre, A, Palese, P

Traffic 2005
7559393 Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import

O'Neill, RE, Jaskunas, R, Blobel, G, Palese, P, Moroianu, J

J Biol Chem 1995
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
intracellular transport of virus (0075733)
Catalyst Activity

structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
structural constituent of nuclear pore (GO:0017056)
This event is regulated
Negatively by
Regulator
ISGylated NS1 [cytosol] (Homo sapiens)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cross References
Mondo
Authored
Gillespie, ME  (2013-11-18)
Reviewed
Gale M, Jr  (2004-05-12)
Created
Garapati, P V  (2011-01-25)
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