ISGylation of host proteins

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
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Many host proteins are targets for ISGylation including constitutively expressed proteins involved in various cellular pathways such as immunity, RNA splicing, chromatin remodeling/polymerase II transcription, stress responses and translation. Many ISG15 target proteins are IFN alpha/beta-induced antiviral proteins such as PKR, MxA, IRF3, and RIG-I, also included are several key regulators of signal transduction such as PLC gamma1, JAK1, STAT1 and ERK1. The contribution of most of these modified proteins to antiviral activity is unclear because the fate of the vast majority of ISGylated target proteins is unknown.
Literature References
PubMed ID Title Journal Year
16139798 Proteomic identification of proteins conjugated to ISG15 in mouse and human cells

Virgin, HW, Zhang, DE, Jacobs, BS, Luo, JK, Borden, EC, Papov, V, Li, J, Zou, W, Lenschow, DJ, Giannakopoulos, NV

Biochem Biophys Res Commun 2005
16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

Denison, C, Krug, RM, Huibregtse, JM, Gygi, S, Zhao, C

Proc Natl Acad Sci U S A 2005
12582176 High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction

Malakhova, OA, Malakhov, MP, Zhang, DE, Jacobs, BS, Borden, EC, Kim, KI

J Biol Chem 2003
Catalyst Activity

ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]

Orthologous Events
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