Reactome | Transfer of ISG15 from E1 to E2 (UBCH8)

Transfer of ISG15 from E1 to E2 (UBCH8)

Stable Identifier

R-HSA-1169404

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated ISG15 linked to UBE1L is transferred to the E2 conjugating enzyme UBCH8.

Literature References

PubMed ID	Title	Journal	Year
11157743	Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein Krug, RM, Yuan, W	EMBO J	2001
15131269	The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein Krug, RM, Beaudenon, SL, Yuan, W, Schulman, BA, Huibregtse, JM, Kelley, ML, Waddell, MB, Zhao, C	Proc Natl Acad Sci U S A	2004
15485925	Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation Virgin, HW, Zhang, DE, Kim, KI, Giannakopoulos, NV	Mol Cell Biol	2004
18583345	The basis for selective E1-E2 interactions in the ISG15 conjugation system Durfee, LA, Huibregtse, JM, Kelley, ML	J Biol Chem	2008