Transfer of ISG15 from E1 to E2 (UBCH8)

Stable Identifier
Reaction [transition]
Homo sapiens
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Activated ISG15 linked to UBE1L is transferred to the E2 conjugating enzyme UBCH8.

Literature References
PubMed ID Title Journal Year
11157743 Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

Krug, RM, Yuan, W

EMBO J 2001
15131269 The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

Krug, RM, Beaudenon, SL, Yuan, W, Schulman, BA, Huibregtse, JM, Kelley, ML, Waddell, MB, Zhao, C

Proc Natl Acad Sci U S A 2004
15485925 Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation

Virgin, HW, Zhang, DE, Kim, KI, Giannakopoulos, NV

Mol Cell Biol 2004
18583345 The basis for selective E1-E2 interactions in the ISG15 conjugation system

Durfee, LA, Huibregtse, JM, Kelley, ML

J Biol Chem 2008
Catalyst Activity

ubiquitin binding activity of UBE2L6 [cytosol]

Orthologous Events
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