ISGylation of viral protein NS1

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Influenza A virus
Locations in the PathwayBrowser
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Some viral proteins are also targeted for ISGylation. The well studied viral protein ISGylation is the modification of the influenza A viral protein NS1, which functions as an IFN antagonist during viral infection. Studies identified seven lysine residues in NS1 as potential ISGylation sites among which K41 (Zhao et al. 2010), K126 and K217 (Tang et al. 2010) were found to be critical. ISGylation at these sites disrupts NS1 association with importin-alpha, a protein required for the nuclear import of NS1.
Literature References
PubMed ID Title Journal Year
20219937 Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein

Garcia-Sastre, A, Wolff, T, van Boheemen, S, Hale, BG, Versteeg, GA, Lenschow, DJ

J Virol 2010
20133869 ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells

Krug, RM, Kuo, RL, Zhao, C, Hsiang, TY

Proc Natl Acad Sci U S A 2010
20385878 Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein

Shan, Y, Liu, X, Zhu, L, Tang, Y, Bu, Z, Wang, C, Feng, H, Chen, H, Zhong, G

J Immunol 2010
Catalyst Activity

ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]

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