Reactome | Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane]

Schema > Complex > Entries

Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-1169198] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SOCS [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1168813] SOCS binding to JAK2 - Homo sapiens [Reaction:R-HSA-1168809] SOCS binding to GHR - Homo sapiens [Reaction:R-HSA-1168445] PTP1B binds the GH receptor complex - Homo sapiens [Reaction:R-HSA-1168393] STAT5 association with GHR - Homo sapiens [Reaction:R-HSA-1168839] SHP1 (PTPN6) binds JAK2 in the receptor complex - Homo sapiens
created	[InstanceEdit:1168903] Jupe, S, 2011-01-10
dbId	1168898
displayName	Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane]
hasComponent	[DefinedSet:R-HSA-982814] Growth Hormone [extracellular region] [Complex:R-HSA-1168890] Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] - Mus musculus [Complex:R-RNO-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] - Rattus norvegicus [Complex:R-CFA-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] - Canis familiaris [Complex:R-BTA-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] - Bos taurus [Complex:R-SSC-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] - Sus scrofa [Complex:R-DRE-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] - Danio rerio [Complex:R-GGA-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] - Gallus gallus
isChimeric	false
maxDepth	4
modified	[InstanceEdit:1169139] Jupe, S, 2011-01-12
name	Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer
producedByEvent	[Reaction:R-HSA-1168894] p-STAT5A/B dissociates from the Growth Hormone receptor - Homo sapiens [Reaction:R-HSA-982807] JAK2 phosphorylation of GHR - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1168898

Referrals

(hasComponent)	[Complex:R-HSA-1169198] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SOCS [plasma membrane] [Complex:R-HSA-1169217] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:CIS/SOCS1-3 [plasma membrane] [Complex:R-HSA-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] [Complex:R-HSA-1168901] Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:p-STAT5 [plasma membrane] [Complex:R-HSA-1168902] Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] [Complex:R-HSA-1169243] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane]
(input)	[Reaction:R-HSA-1168813] SOCS binding to JAK2 [Reaction:R-HSA-1168809] SOCS binding to GHR [Reaction:R-HSA-1168445] PTP1B binds the GH receptor complex [Reaction:R-HSA-1168393] STAT5 association with GHR [Reaction:R-HSA-1168839] SHP1 (PTPN6) binds JAK2 in the receptor complex
(output)	[Reaction:R-HSA-1168894] p-STAT5A/B dissociates from the Growth Hormone receptor [Reaction:R-HSA-982807] JAK2 phosphorylation of GHR

© 2026 Reactome

Cite Us!