Reactome | Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane]

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Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:1169248] protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-1169192] PTP1B dephosphorylates GHR - Homo sapiens [Reaction:R-HSA-1169210] PTP1B dephosphorylates JAK2 - Homo sapiens
created	[InstanceEdit:1169230] Jupe, S, 2011-01-14
dbId	1169227
displayName	Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane]
hasComponent	[Complex:R-HSA-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-210625] PTPN1 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] - Mus musculus [Complex:R-RNO-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] - Canis familiaris [Complex:R-BTA-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] - Bos taurus [Complex:R-SSC-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] - Sus scrofa [Complex:R-DRE-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] - Danio rerio [Complex:R-GGA-1169227] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] - Gallus gallus
isChimeric	false
maxDepth	5
modified	[InstanceEdit:1369100] Jupe, S, 2011-07-04
name	Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2
producedByEvent	[Reaction:R-HSA-1168445] PTP1B binds the GH receptor complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1169227

Referrals

(input)	[Reaction:R-HSA-1169192] PTP1B dephosphorylates GHR [Reaction:R-HSA-1169210] PTP1B dephosphorylates JAK2
(output)	[Reaction:R-HSA-1168445] PTP1B binds the GH receptor complex
(physicalEntity)	[CatalystActivity:1169248] protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane]

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