Reactome | Addition of nucleotides leads to transcript elongation

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Addition of nucleotides leads to transcript elongation Show undefined attributes

authored	[InstanceEdit:113792] Gopinathrao, G, 2004-06-22 14:12:50
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75957] Conaway, JW, Conaway, RC, 2003-09-11
dbId	112385
displayName	Addition of nucleotides leads to transcript elongation
eventOf	[Pathway:R-HSA-75955] RNA Polymerase II Transcription Elongation - Homo sapiens
figure	[Figure:113803] /figures/elong1.jpg
followingEvent	[Reaction:R-HSA-113429] Elongating transcript encounters a lesion in the template - Homo sapiens [Reaction:R-HSA-113411] 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing - Homo sapiens [Reaction:R-HSA-113414] 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest - Homo sapiens [Reaction:R-HSA-113412] Pol II elongation complex moves on the template as transcript elongates - Homo sapiens
input	[Complex:R-HSA-112433] Elongation complex [nucleoplasm] [SimpleEntity:R-ALL-9757634] NTP [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:113806] Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. [LiteratureReference:113805] Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Addition of nucleotides leads to transcript elongation
orthologousEvent	[Reaction:R-HSA-167181] Addition of nucleotides leads to HIV-1 transcript elongation - Homo sapiens [Reaction:R-HSA-167087] Limited elongation of the HIV-1 transcript - Homo sapiens [Reaction:R-CEL-112385] Addition of nucleotides leads to transcript elongation - Caenorhabditis elegans [Reaction:R-DME-112385] Addition of nucleotides leads to transcript elongation - Drosophila melanogaster [Reaction:R-GGA-112385] Addition of nucleotides leads to transcript elongation - Gallus gallus [Reaction:R-XTR-112385] Addition of nucleotides leads to transcript elongation - Xenopus tropicalis [Reaction:R-DRE-112385] Addition of nucleotides leads to transcript elongation - Danio rerio [Reaction:R-SSC-112385] Addition of nucleotides leads to transcript elongation - Sus scrofa [Reaction:R-BTA-112385] Addition of nucleotides leads to transcript elongation - Bos taurus [Reaction:R-CFA-112385] Addition of nucleotides leads to transcript elongation - Canis familiaris [Reaction:R-RNO-112385] Addition of nucleotides leads to transcript elongation - Rattus norvegicus [Reaction:R-MMU-112385] Addition of nucleotides leads to transcript elongation - Mus musculus
output	[Complex:R-HSA-113719] Processive elongation complex [nucleoplasm] [Complex:R-HSA-109634] TFIIH [nucleoplasm]
precedingEvent	[Reaction:R-HSA-112379] Recruitment of elongation factors to form elongation complex - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-112385
summation	[Summation:113804] High-resolution structures of free, catalytically active yea...
updateTrackers	[UpdateTracker:9775412] Update Tracker - [Reaction:112385] Addition of nucleotides leads to transcript elongation - v79:[add_removeInput] [UpdateTracker:9784186] Update Tracker - [Reaction:112385] Addition of nucleotides leads to transcript elongation - v54:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9775412] Update Tracker - [Reaction:112385] Addition of nucleotides leads to transcript elongation - v79:[add_removeInput] [UpdateTracker:9784186] Update Tracker - [Reaction:112385] Addition of nucleotides leads to transcript elongation - v54:[addLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-113429] Elongating transcript encounters a lesion in the template [Reaction:R-HSA-113411] 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing [Reaction:R-HSA-113414] 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest [Reaction:R-HSA-113412] Pol II elongation complex moves on the template as transcript elongates
(hasEvent)	[Pathway:R-HSA-75955] RNA Polymerase II Transcription Elongation

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