Reactome | SRC autophosphorylation is positively regulated by InlA-bound CDH1

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SRC autophosphorylation is positively regulated by InlA-bound CDH1 Show undefined attributes

authored	[InstanceEdit:8876400] Orlic-Milacic, Marija, 2016-06-14
catalystActivity	[CatalystActivity:8876921] protein tyrosine kinase activity of MyrG-SRC [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:25409] peptidoglycan-based cell wall
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
crossReference	[DatabaseIdentifier:12020818] Mondo:0005828
dbId	112333
disease	[Disease:8875363] listeriosis
displayName	SRC autophosphorylation is positively regulated by InlA-bound CDH1
edited	[InstanceEdit:8943577] Orlic-Milacic, Marija, 2016-10-26
entityOnOtherCell	[EntityWithAccessionedSequence:R-LMO-8876505] InlA [peptidoglycan-based cell wall] - Listeria monocytogenes
eventOf	[Pathway:R-HSA-8876493] InlA-mediated entry of Listeria monocytogenes into host cells - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8876948] SRC phosphorylates InlA-bound CDH1 and CTNNB1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-8876922] MyrG-SRC [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:112334] Regulation, substrates and functions of src. [LiteratureReference:8876932] Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells
maxDepth	1
modified	[InstanceEdit:9836317] D'Eustachio, Peter, 2023-05-25
name	SRC autophosphorylation is positively regulated by InlA-bound CDH1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-1810408] MyrG-p-Y419-SRC [plasma membrane]
precedingEvent	[Reaction:R-HSA-8876497] InlA binds CDH1 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8876920] Positive regulation by 'InlA:CDH1:CTNNB1:CTNND1 [plasma membrane]'
relatedSpecies	[Species:8875362] Listeria monocytogenes
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8943564] Schwerk, Christian, 2016-10-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-112333
summation	[Summation:8876950] SRC activation involves autophosphorylation at tyrosine resi...

Referrals

(hasEvent)	[Pathway:R-HSA-8876493] InlA-mediated entry of Listeria monocytogenes into host cells
(precedingEvent)	[BlackBoxEvent:R-HSA-8876948] SRC phosphorylates InlA-bound CDH1 and CTNNB1

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