SRC autophosphorylation is positively regulated by InlA-bound CDH1

Stable Identifier
R-HSA-112333
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, cytosol, peptidoglycan-based cell wall
ReviewStatus
5/5
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SRC autophosphorylation is positively regulated by InlA-bound CDH1
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SRC activation involves autophosphorylation at tyrosine residue Y419 (Brown and Cooper 1996). Binding of the Listeria monocytogenes cell wall protein InlA to E-cadherin (CDH1) triggers SRC autophosphorylation at Y419 through an unknown mechanism (Sousa et al. 2007). CDH1 engagement (adhesion) at cell-cell contacts is also known to induce SRC autophosphorylation (Fujita et al. 2002, McLachlan et al. 2007) and may involve integrins (Avizienyte et al. 2002, Martinez-Rico et al. 2010), but the process has not been fully elucidated.
Literature References
PubMed ID Title Journal Year
8672527 Regulation, substrates and functions of src.

Brown, MT, Cooper, JA

Biochim Biophys Acta 1996
17627624 Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells

Bougnères, L, Lecuit, M, Cabanes, D, Cossart, P, Tran-Van-Nhieu, G, Sousa, S, Sansonetti, P

Cell. Microbiol. 2007
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of MyrG-SRC [plasma membrane]

Physical Entity
MyrG-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Positively by
Regulator
InlA:CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
Disease
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Charalambous, M  (2004-04-29)
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