SRC autophosphorylation is positively regulated by InlA-bound CDH1

Stable Identifier
R-HSA-112333
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
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SRC activation involves autophosphorylation at tyrosine residue Y419 (Brown and Cooper 1996). Binding of the Listeria monocytogenes cell wall protein InlA to E-cadherin (CDH1) triggers SRC autophosphorylation at Y419 through an unknown mechanism (Sousa et al. 2007). CDH1 engagement (adhesion) at cell-cell contacts is also known to induce SRC autophosphorylation (Fujita et al. 2002, McLachlan et al. 2007) and may involve integrins (Avizienyte et al. 2002, Martinez-Rico et al. 2010), but the process has not been fully elucidated.

Literature References
PubMed ID Title Journal Year
17627624 Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells

Sousa, S, Cabanes, D, Bougnères, L, Lecuit, M, Sansonetti, P, Tran-Van-Nhieu, G, Cossart, P

Cell. Microbiol. 2007
8672527 Regulation, substrates and functions of src.

Brown, MT, Cooper, JA

Biochim Biophys Acta 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of MyrG-SRC [plasma membrane]
Physical Entity
Activity
This event is regulated
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Reviewed
Created