SRC autophosphorylation is positively regulated by InlA-bound CDH1

Stable Identifier
Reaction [omitted]
Homo sapiens
Related Species
Listeria monocytogenes
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SRC activation involves autophosphorylation at tyrosine residue Y419 (Brown and Cooper 1996). Binding of the Listeria monocytogenes cell wall protein InlA to E-cadherin (CDH1) triggers SRC autophosphorylation at Y419 through an unknown mechanism (Sousa et al. 2007). CDH1 engagement (adhesion) at cell-cell contacts is also known to induce SRC autophosphorylation (Fujita et al. 2002, McLachlan et al. 2007) and may involve integrins (Avizienyte et al. 2002, Martinez-Rico et al. 2010), but the process has not been fully elucidated.

Literature References
PubMed ID Title Journal Year
8672527 Regulation, substrates and functions of src.

Brown, MT, Cooper, JA

Biochim Biophys Acta 1996
17627624 Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells

Bougnères, L, Lecuit, M, Cabanes, D, Cossart, P, Tran-Van-Nhieu, G, Sousa, S, Sansonetti, P

Cell. Microbiol. 2007
Catalyst Activity

protein tyrosine kinase activity of MyrG-SRC [plasma membrane]

This event is regulated
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
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