Reactome | SRC activation involves autophosphorylation at tyrosine resi...

Schema > Summation > Entries

created	[InstanceEdit:8876954] Orlic-Milacic, Marija, 2016-06-17
dbId	8876950
displayName	SRC activation involves autophosphorylation at tyrosine resi...
literatureReference	[LiteratureReference:8876930] Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex [LiteratureReference:112334] Regulation, substrates and functions of src. [LiteratureReference:8876932] Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells [LiteratureReference:8876960] E-cadherin adhesion activates c-Src signaling at cell-cell contacts [LiteratureReference:8876964] Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling [LiteratureReference:8876956] Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility
schemaClass	Summation
text	SRC activation involves autophosphorylation at tyrosine residue Y419 (Brown and Cooper 1996). Binding of the Listeria monocytogenes cell wall protein InlA to E-cadherin (CDH1) triggers SRC autophosphorylation at Y419 through an unknown mechanism (Sousa et al. 2007). CDH1 engagement (adhesion) at cell-cell contacts is also known to induce SRC autophosphorylation (Fujita et al. 2002, McLachlan et al. 2007) and may involve integrins (Avizienyte et al. 2002, Martinez-Rico et al. 2010), but the process has not been fully elucidated.

(summation)

Cite Us!