Reactome | IL6ST is tyrosine phosphorylated

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IL6ST is tyrosine phosphorylated Show undefined attributes

authored	[InstanceEdit:1164950] Ray, K, 2010-12-13
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1112527] Jupe, S, 2010-12-03
dbId	1112510
displayName	IL6ST is tyrosine phosphorylated
edited	[InstanceEdit:1112767] Jupe, S, 2010-12-10
eventOf	[Pathway:R-HSA-1059683] Interleukin-6 signaling - Homo sapiens [Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens
followingEvent	[Reaction:R-HSA-1112755] SOCS3 binds IL6ST - Homo sapiens [Reaction:R-HSA-1112565] Tyrosine phosphorylated IL6ST binds STAT1,STAT3 - Homo sapiens [Reaction:R-HSA-1112708] PTPN11 binds p-Y759-IL6ST - Homo sapiens [Reaction:R-HSA-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Homo sapiens
input	20 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1112515] IL6 receptor hexamer:Activated JAKs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1164952] Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes [LiteratureReference:1112534] Tracking STAT nuclear traffic
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IL6ST is tyrosine phosphorylated Phosphorylation of gp130
orthologousEvent	[BlackBoxEvent:R-GGA-1112510] IL6ST is tyrosine phosphorylated - Gallus gallus [BlackBoxEvent:R-XTR-1112510] IL6ST is tyrosine phosphorylated - Xenopus tropicalis [BlackBoxEvent:R-DRE-1112510] IL6ST is tyrosine phosphorylated - Danio rerio [BlackBoxEvent:R-SSC-1112510] IL6ST is tyrosine phosphorylated - Sus scrofa [BlackBoxEvent:R-BTA-1112510] IL6ST is tyrosine phosphorylated - Bos taurus [BlackBoxEvent:R-CFA-1112510] IL6ST is tyrosine phosphorylated - Canis familiaris [BlackBoxEvent:R-RNO-1112510] IL6ST is tyrosine phosphorylated - Rattus norvegicus [BlackBoxEvent:R-MMU-1112510] IL6ST is tyrosine phosphorylated - Mus musculus
output	20 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1112514] JAK activation - Homo sapiens
releaseDate	2011-03-15
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1214159] Rose-John, S, 2011-02-11 [InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1112510
summation	[Summation:1112600] Activated JAKs are believed to be responsible for phosphoryl...
updateTrackers	[UpdateTracker:9781906] Update Tracker - [BlackBoxEvent:1112510] IL6ST is tyrosine phosphorylated - v60:[modifyText] [UpdateTracker:9984614] Update Tracker - [BlackBoxEvent:1112510] IL6ST is tyrosine phosphorylated - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781906] Update Tracker - [BlackBoxEvent:1112510] IL6ST is tyrosine phosphorylated - v60:[modifyText] [UpdateTracker:9984614] Update Tracker - [BlackBoxEvent:1112510] IL6ST is tyrosine phosphorylated - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-HSA-1059683] Interleukin-6 signaling
(precedingEvent)	[Reaction:R-HSA-1112755] SOCS3 binds IL6ST [Reaction:R-HSA-1112565] Tyrosine phosphorylated IL6ST binds STAT1,STAT3 [Reaction:R-HSA-1112708] PTPN11 binds p-Y759-IL6ST [Reaction:R-HSA-9958878] Tyrosine phosphorylated IL6ST binds STAT3