Reactome | IL6ST is tyrosine phosphorylated

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IL6ST is tyrosine phosphorylated Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10593077
displayName	IL6ST is tyrosine phosphorylated
eventOf	[Pathway:R-DRE-1059683] Interleukin-6 signaling - Danio rerio [Pathway:R-DRE-9958825] Activation of STAT3 by cadherin engagement - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-1112755] SOCS3 binds IL6ST - Danio rerio [Reaction:R-DRE-1112565] Tyrosine phosphorylated IL6ST binds STAT1,STAT3 - Danio rerio
inferredFrom	[BlackBoxEvent:R-HSA-1112510] IL6ST is tyrosine phosphorylated - Homo sapiens
input	20 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DRE-1112515] IL6 receptor hexamer:Activated JAKs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL6ST is tyrosine phosphorylated Phosphorylation of gp130
output	20 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DRE-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
precedingEvent	[BlackBoxEvent:R-DRE-1112514] JAK activation - Danio rerio
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68323] Danio rerio
stId	R-DRE-1112510
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-DRE-1059683] Interleukin-6 signaling
(precedingEvent)	[Reaction:R-DRE-1112755] SOCS3 binds IL6ST [Reaction:R-DRE-1112565] Tyrosine phosphorylated IL6ST binds STAT1,STAT3
(inferredTo)	[BlackBoxEvent:R-HSA-1112510] IL6ST is tyrosine phosphorylated

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