Reactome | Tyrosine phosphorylated IL6ST binds STAT3

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Tyrosine phosphorylated IL6ST binds STAT3 Show undefined attributes

authored	[InstanceEdit:9958914] Orlic-Milacic, Marija, 2025-06-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9958870] Orlic-Milacic, Marija, 2025-06-25
dbId	9958878
displayName	Tyrosine phosphorylated IL6ST binds STAT3
edited	[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
eventOf	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens
followingEvent	[Reaction:R-HSA-9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol] [Complex:R-HSA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1112531] Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation [LiteratureReference:1112547] Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Tyrosine phosphorylated IL6ST binds STAT3
orthologousEvent	[Reaction:R-GGA-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Gallus gallus [Reaction:R-XTR-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Xenopus tropicalis [Reaction:R-SSC-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Sus scrofa [Reaction:R-BTA-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Bos taurus [Reaction:R-CFA-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Canis familiaris [Reaction:R-RNO-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Rattus norvegicus [Reaction:R-MMU-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Mus musculus
output	[Complex:R-HSA-9958926] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1112510] IL6ST is tyrosine phosphorylated - Homo sapiens
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9958878
summation	[Summation:9958932] STAT3 binds to IL6ST (gp130) via phosphotyrosine residues 90...

Referrals

(hasEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement
(precedingEvent)	[Reaction:R-HSA-9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor