Reactome | APEX1:AP-dsDNA [nucleoplasm]

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APEX1:AP-dsDNA [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10233879] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-CFA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10233856
displayName	APEX1:AP-dsDNA [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-CFA-50119] APEX1 [nucleoplasm] [GenomeEncodedEntity:R-CFA-110187] Ghost homologue of AP-dsDNA [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-110332] APEX1:AP-dsDNA [nucleoplasm] - Homo sapiens
maxDepth	2
name	APEX1:AP-dsDNA
producedByEvent	[Reaction:R-CFA-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-CFA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-CFA-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-CFA-110350] Displacement of TDG glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-CFA-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-CFA-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-CFA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-CFA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-110332
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-CFA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
(physicalEntity)	[CatalystActivity:10233879] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
(output)	[Reaction:R-CFA-110350] Displacement of TDG glycosylase by APEX1 at the AP site [Reaction:R-CFA-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site [Reaction:R-CFA-110349] Displacement of UNG glycosylase by APEX1 at the AP site [Reaction:R-CFA-110356] Displacement of MPG glycosylase by APEX1 at the AP site [Reaction:R-CFA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Reaction:R-CFA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site [Reaction:R-CFA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Reaction:R-CFA-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site
(inferredTo)	[Complex:R-HSA-110332] APEX1:AP-dsDNA [nucleoplasm]

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