Reactome | Cleavage of the damaged purine

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Cleavage of the damaged purine Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
dbId	110331
displayName	Cleavage of the damaged purine
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-73927] Depurination - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18784] depurination
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Homo sapiens [Reaction:R-HSA-110248] Cleavage of 3-methyladenine by MPG glycosylase - Homo sapiens [Reaction:R-HSA-110250] Cleavage of ethenoadenine by MPG glycosylase - Homo sapiens [Reaction:R-HSA-110251] Cleavage of hypoxanthine by MPG glycosylase - Homo sapiens [Reaction:R-HSA-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Homo sapiens [Reaction:R-HSA-9629216] NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA - Homo sapiens [Reaction:R-HSA-9629470] NEIL3 cleaves 5-guanidinohydantoin - Homo sapiens [Reaction:R-HSA-9629483] NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA - Homo sapiens [Reaction:R-HSA-9629492] NEIL3 cleaves spiroiminodihydantoin - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-12-10
literatureReference	[LiteratureReference:5634855] Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases [LiteratureReference:110557] Quality control by DNA repair
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Cleavage of the damaged purine
orthologousEvent	[Pathway:R-PFA-110331] Cleavage of the damaged purine - Plasmodium falciparum [Pathway:R-SCE-110331] Cleavage of the damaged purine - Saccharomyces cerevisiae [Pathway:R-SPO-110331] Cleavage of the damaged purine - Schizosaccharomyces pombe [Pathway:R-DDI-110331] Cleavage of the damaged purine - Dictyostelium discoideum [Pathway:R-DME-110331] Cleavage of the damaged purine - Drosophila melanogaster [Pathway:R-GGA-110331] Cleavage of the damaged purine - Gallus gallus [Pathway:R-XTR-110331] Cleavage of the damaged purine - Xenopus tropicalis [Pathway:R-DRE-110331] Cleavage of the damaged purine - Danio rerio [Pathway:R-SSC-110331] Cleavage of the damaged purine - Sus scrofa [Pathway:R-BTA-110331] Cleavage of the damaged purine - Bos taurus [Pathway:R-CFA-110331] Cleavage of the damaged purine - Canis familiaris [Pathway:R-RNO-110331] Cleavage of the damaged purine - Rattus norvegicus [Pathway:R-MMU-110331] Cleavage of the damaged purine - Mus musculus
precedingEvent	[Pathway:R-HSA-110330] Recognition and association of DNA glycosylase with site containing an affected purine - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-110331
summation	[Summation:212500] Damaged purines are cleaved from the sugar-phosphate backbon...
updateTrackers	[UpdateTracker:9791981] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v24:[addSummation] [UpdateTracker:9785150] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v52:[modifyText, removeHasEvent, updateContainedRLE] [UpdateTracker:9779474] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v65:[updateContainedRLE] [UpdateTracker:9785807] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v51:[addLiteratureReference, updateContainedRLE] [UpdateTracker:9778535] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v68:[addHasEvent] [UpdateTracker:9777426] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v71:[updateContainedRLE] [UpdateTracker:9779242] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v66:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9791981] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v24:[addSummation]
[UpdateTracker:9785150] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v52:[modifyText, removeHasEvent, updateContainedRLE]
[UpdateTracker:9779474] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v65:[updateContainedRLE]
[UpdateTracker:9785807] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v51:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9778535] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v68:[addHasEvent]
[UpdateTracker:9777426] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v71:[updateContainedRLE]
[UpdateTracker:9779242] Update Tracker - [Pathway:110331] Cleavage of the damaged purine - v66:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-73927] Depurination

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