Cleavage of the damaged purine

Stable Identifier
R-HSA-110331
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cleavage of the damaged purine
Click the image above or here to open this pathway in the Pathway Browser

Damaged purines are cleaved from the sugar-phosphate backbone by purine-specific glycosylases (Saparbaev and Laval 1994, Lindahl and Wood 1999).

Literature References
PubMed ID Title Journal Year
8016081 Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases

Saparbaev, M, Laval, J

Proc. Natl. Acad. Sci. U.S.A. 1994
10583946 Quality control by DNA repair

Lindahl, T, Wood, RD

Science 1999
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
depurination (0045007)
Orthologous Events
Cleavage of the damaged purine (Bos taurus)
Cleavage of the damaged purine (Canis familiaris)
Cleavage of the damaged purine (Danio rerio)
Cleavage of the damaged purine (Dictyostelium discoideum)
Cleavage of the damaged purine (Drosophila melanogaster)
Cleavage of the damaged purine (Gallus gallus)
Cleavage of the damaged purine (Mus musculus)
Cleavage of the damaged purine (Plasmodium falciparum)
Cleavage of the damaged purine (Rattus norvegicus)
Cleavage of the damaged purine (Saccharomyces cerevisiae)
Cleavage of the damaged purine (Schizosaccharomyces pombe)
Cleavage of the damaged purine (Sus scrofa)
Cleavage of the damaged purine (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)