Reactome | Excision of 8-oxoguanine by OGG1 glycosylase

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Excision of 8-oxoguanine by OGG1 glycosylase Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5643997] oxidized purine nucleobase lesion DNA N-glycosylase activity of OGG1:(8oxoG:Cyt)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
dbId	110243
diseaseReaction	[FailedReaction:R-HSA-9656250] Defective OGG1 mutants do not excise 8-oxoguanine - Homo sapiens
displayName	Excision of 8-oxoguanine by OGG1 glycosylase
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03 [InstanceEdit:9663704] Orlic-Milacic, Marija, 2019-10-10
eventOf	[Pathway:R-HSA-110331] Cleavage of the damaged purine - Homo sapiens
followingEvent	[Reaction:R-HSA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-5649701] NEIL1,NEIL2 displace OGG1 from AP-dsDNA - Homo sapiens
input	[Complex:R-HSA-110185] OGG1:(8oxoG:Cyt)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5635989] Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue [LiteratureReference:5635981] Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase [LiteratureReference:5635964] Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase [LiteratureReference:5635990] Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae [LiteratureReference:5635965] Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites [LiteratureReference:5635975] Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Excision of 8-oxoguanine by OGG1 glycosylase
orthologousEvent	[Reaction:R-PFA-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Plasmodium falciparum [Reaction:R-SCE-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Saccharomyces cerevisiae [Reaction:R-DDI-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Dictyostelium discoideum [Reaction:R-DME-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Drosophila melanogaster [Reaction:R-GGA-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Gallus gallus [Reaction:R-XTR-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Xenopus tropicalis [Reaction:R-DRE-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Danio rerio [Reaction:R-BTA-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Bos taurus [Reaction:R-CFA-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Canis familiaris [Reaction:R-RNO-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Rattus norvegicus [Reaction:R-MMU-110243] Excision of 8-oxoguanine by OGG1 glycosylase - Mus musculus
output	[SimpleEntity:R-ALL-110242] 8oxoG [nucleoplasm] [Complex:R-HSA-110195] OGG1:AP-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-110235] OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22 [InstanceEdit:9663702] Vlahopoulos, Spiros, 2019-10-02 [InstanceEdit:9663703] Boldogh, Istvan, 2019-10-08
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-110243
summation	[Summation:178541] OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise...
updateTrackers	[UpdateTracker:9785307] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v52:[add_removeCatalystActivity, modifyText, removeLiteratureReference] [UpdateTracker:9785737] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v51:[addLiteratureReference, modifyText] [UpdateTracker:9777493] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v71:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785307] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v52:[add_removeCatalystActivity, modifyText, removeLiteratureReference] [UpdateTracker:9785737] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v51:[addLiteratureReference, modifyText] [UpdateTracker:9777493] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v71:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-9656250] Defective OGG1 mutants do not excise 8-oxoguanine
(precedingEvent)	[Reaction:R-HSA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Reaction:R-HSA-5649701] NEIL1,NEIL2 displace OGG1 from AP-dsDNA
(hasEvent)	[Pathway:R-HSA-110331] Cleavage of the damaged purine

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