Reactome | Cleavage of adenine mispaired with 8-oxoguanine by MUTYH

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Cleavage of adenine mispaired with 8-oxoguanine by MUTYH Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5649473] DNA N-glycosylase activity of MUTYH:(8oxoG:Ade)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
dbId	110246
diseaseReaction	[FailedReaction:R-HSA-9605313] Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine - Homo sapiens
displayName	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03 [InstanceEdit:9612698] Orlic-Milacic, Marija, 2018-06-29
eventOf	[Pathway:R-HSA-110331] Cleavage of the damaged purine - Homo sapiens
followingEvent	[Reaction:R-HSA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Homo sapiens
input	[Complex:R-HSA-110199] MUTYH:(8oxoG:Ade)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5635925] Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria [LiteratureReference:5635939] hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs [LiteratureReference:9606843] Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH
orthologousEvent	[Reaction:R-PFA-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Plasmodium falciparum [Reaction:R-SPO-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Schizosaccharomyces pombe [Reaction:R-DDI-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Dictyostelium discoideum [Reaction:R-GGA-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Gallus gallus [Reaction:R-XTR-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Xenopus tropicalis [Reaction:R-DRE-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Danio rerio [Reaction:R-SSC-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Sus scrofa [Reaction:R-BTA-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Bos taurus [Reaction:R-CFA-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Canis familiaris [Reaction:R-RNO-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Rattus norvegicus [Reaction:R-MMU-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Mus musculus
output	[SimpleEntity:R-ALL-5635947] Ade [nucleoplasm] [Complex:R-HSA-110200] MUTYH:AP-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-110237] MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22 [InstanceEdit:9612701] Nakabeppu, Yusaku, 2018-06-28
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-110246
summation	[Summation:178535] MUTYH (MYH) functions as an adenine DNA glycosylase and remo...
updateTrackers	[UpdateTracker:9779306] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v65:[addLiteratureReference, modifyText] [UpdateTracker:9779288] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v66:[modifyText] [UpdateTracker:9785818] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v51:[add_removeOutput, modifyText] [UpdateTracker:9785170] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v52:[add_removeCatalystActivity, add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9779306] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v65:[addLiteratureReference, modifyText] [UpdateTracker:9779288] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v66:[modifyText] [UpdateTracker:9785818] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v51:[add_removeOutput, modifyText] [UpdateTracker:9785170] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v52:[add_removeCatalystActivity, add_removeLiteratureReference]
(normalReaction)	[FailedReaction:R-HSA-9605313] Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine
(precedingEvent)	[Reaction:R-HSA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site
(hasEvent)	[Pathway:R-HSA-110331] Cleavage of the damaged purine

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