Reactome | Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2

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Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 Show undefined attributes

authored	[InstanceEdit:158672] Charalambous, M, 2005-02-04 06:50:22
category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
dbId	109864
displayName	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-112411] MAPK1 (ERK2) activation - Homo sapiens
figure	[Figure:158659] /figures/Diss_MEK_ERK.jpg
followingEvent	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
input	[Complex:R-HSA-109854] p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208207] Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
orthologousEvent	[Reaction:R-GGA-451505] Dissociation of phospho ERK2 :phospho MEK2 complex - Gallus gallus [Reaction:R-DDI-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Dictyostelium discoideum [Reaction:R-CEL-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Caenorhabditis elegans [Reaction:R-DME-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Drosophila melanogaster [Reaction:R-DRE-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Danio rerio [Reaction:R-SSC-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Sus scrofa [Reaction:R-CFA-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Canis familiaris [Reaction:R-RNO-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Rattus norvegicus [Reaction:R-MMU-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-109848] p-S,T-MAP2K2 [cytosol] [EntityWithAccessionedSequence:R-HSA-109853] p-T185,Y187-MAPK1 [cytosol]
precedingEvent	[Reaction:R-HSA-109862] MAP2K2 phosphorylates MAPK1 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1047549] Gillespie, ME, 2010-11-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109864
summation	[Summation:158663] MAP2K2 (MEK2) dissociates from phosphorylated MAPK1 (ERK2), ...
updateTrackers	[UpdateTracker:9781181] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v61:[addLiteratureReference, modifyText] [UpdateTracker:9784554] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v53:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781181] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v61:[addLiteratureReference, modifyText] [UpdateTracker:9784554] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v53:[modifyText]
(hasEvent)	[Pathway:R-HSA-112411] MAPK1 (ERK2) activation
(precedingEvent)	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize