MAP2K2 phosphorylates MAPK1

Stable Identifier
R-HSA-109862
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MAP2K2 phosphorylates MAPK1
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MAP2K2 (MEK2) phosphorylates MAPK1 (ERK2). Phosphorylation of MAPK1 activates its kinase activity.

Literature References
PubMed ID Title Journal Year
22177953 MEK1/2 dual-specificity protein kinases: structure and regulation

Roskoski, R Jr

Biochem. Biophys. Res. Commun. 2012
8388392 Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.

Zheng, CF, Guan, KL

J Biol Chem 1993
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Catalyst Activity

protein serine/threonine kinase activity of p-S,T-MAP2K2:MAPK1 [cytosol]

Physical Entity
p-S,T-MAP2K2:MAPK1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MAP2K2 phosphorylates MAPK1 (Bos taurus)
MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)
MAP2K2 phosphorylates MAPK1 (Canis familiaris)
MAP2K2 phosphorylates MAPK1 (Danio rerio)
MAP2K2 phosphorylates MAPK1 (Dictyostelium discoideum)
MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)
MAP2K2 phosphorylates MAPK1 (Mus musculus)
MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)
MAP2K2 phosphorylates MAPK1 (Saccharomyces cerevisiae)
MAP2K2 phosphorylates MAPK1 (Schizosaccharomyces pombe)
MAP2K2 phosphorylates MAPK1 (Sus scrofa)
activated MEK2 phosphorylates ERK2 (Gallus gallus)
Authored
Charalambous, M  (2005-02-04)
Reviewed
Greene, LA  (2007-11-08)
Created
Charalambous, M  (2004-04-29)
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