MAP2K1 phosphorylates MAPK3

Stable Identifier
R-HSA-109860
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAP2K1 (also known as MEK1) phosphorylates the critical Thr202 and Tyr204 on MAPK3 (ERK1), converting two ATP to ADP. Phosphorylation of MAPK3 activates its kinase activity.

MAP2K1 activation requires the phosphorylation of two serine residues (S218 and S222) in the activation loop.

Literature References
PubMed ID Title Journal Year
23954936 Mitogen-activated protein kinases in innate immunity

Arthur, JS, Ley, SC

Nat. Rev. Immunol. 2013
22177953 MEK1/2 dual-specificity protein kinases: structure and regulation

Roskoski, R Jr

Biochem. Biophys. Res. Commun. 2012
8388392 Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.

Zheng, CF, Guan, KL

J Biol Chem 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-2S-MAP2K1:MAPK3 [cytosol]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
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Reviewed
Created