The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).
Testa, JR, Cheng, JQ, Jove, R, Liu, AX, Nicosia, SV, Hamilton, TC
Kulkarni, RN, Herzig, S, Du, K, Montminy, M
Gaffney, PR, Painter, GF, Stephens, L, McCormick, F, Hawkins, PT, Anderson, K, Reese, CB, Holmes, AB, Coadwell, J, Stokoe, D, Tempst, P, Erdjument-Bromage, H
Kaech, S, Maira, SM, Brazil, DP, Galetic, I, Ingley, E, Thelen, M, Hemmings, BA
Grove, SJ, Gigg, R, Alessi, DR, Holmes, AB, Downes, CP, James, SR
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