AKT2 binds PIP3

Stable Identifier
R-HSA-109700
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
PKB attachment to plasma membrane
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The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).

Literature References
PubMed ID Title Journal Year
9679957 AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells

Testa, JR, Cheng, JQ, Jove, R, Liu, AX, Nicosia, SV, Hamilton, TC

Cancer Res. 1998
12791994 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

Kulkarni, RN, Herzig, S, Du, K, Montminy, M

Science 2003
9445477 Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

Gaffney, PR, Painter, GF, Stephens, L, McCormick, F, Hawkins, PT, Anderson, K, Reese, CB, Holmes, AB, Coadwell, J, Stokoe, D, Tempst, P, Erdjument-Bromage, H

Science 1998
11598301 Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

Kaech, S, Maira, SM, Brazil, DP, Galetic, I, Ingley, E, Thelen, M, Hemmings, BA

Science 2001
8645147 Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

Grove, SJ, Gigg, R, Alessi, DR, Holmes, AB, Downes, CP, James, SR

Biochem J 1996
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