The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).
Kulkarni, RN, Herzig, S, Du, K, Montminy, M
Grove, SJ, Gigg, R, Alessi, DR, Holmes, AB, Downes, CP, James, SR
Kaech, S, Maira, SM, Brazil, DP, Galetic, I, Ingley, E, Thelen, M, Hemmings, BA
Gaffney, PR, Painter, GF, Stephens, L, McCormick, F, Hawkins, PT, Anderson, K, Reese, CB, Holmes, AB, Coadwell, J, Stokoe, D, Tempst, P, Erdjument-Bromage, H
Testa, JR, Cheng, JQ, Jove, R, Liu, AX, Nicosia, SV, Hamilton, TC
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