AKT2 binds PIP3

Stable Identifier
R-HSA-109700
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
PKB attachment to plasma membrane
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AKT2 binds PIP3
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The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).

Literature References
PubMed ID Title Journal Year
8645147 Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

James, SR, Downes, CP, Gigg, R, Grove, SJ, Holmes, AB, Alessi, DR

Biochem J 1996
12791994 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

Du, K, Herzig, S, Kulkarni, RN, Montminy, M

Science 2003
11598301 Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

Maira, SM, Galetic, I, Brazil, DP, Kaech, S, Ingley, E, Thelen, M, Hemmings, BA

Science 2001
9445477 Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

Stephens, L, Anderson, K, Stokoe, D, Erdjument-Bromage, H, Painter, GF, Holmes, AB, Gaffney, PR, Reese, CB, McCormick, F, Tempst, P, Coadwell, J, Hawkins, PT

Science 1998
9679957 AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells

Liu, AX, Testa, JR, Hamilton, TC, Jove, R, Nicosia, SV, Cheng, JQ

Cancer Res. 1998
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Orthologous Events
AKT2 binds PIP3 (Bos taurus)
AKT2 binds PIP3 (Caenorhabditis elegans)
AKT2 binds PIP3 (Canis familiaris)
AKT2 binds PIP3 (Danio rerio)
AKT2 binds PIP3 (Dictyostelium discoideum)
AKT2 binds PIP3 (Drosophila melanogaster)
AKT2 binds PIP3 (Mus musculus)
AKT2 binds PIP3 (Rattus norvegicus)
AKT2 binds PIP3 (Sus scrofa)
Created
de Bono, B  (2004-01-20)