Reactome | AKT2 binds PIP3

AKT2 binds PIP3

Stable Identifier

R-HSA-109700

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Synonyms

PKB attachment to plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        AKT2 binds PIP3 (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        AKT2 binds PIP3 (Homo sapiens)

General

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The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12791994	TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Kulkarni, RN, Herzig, S, Du, K, Montminy, M	Science	2003
8645147	Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation Grove, SJ, Gigg, R, Alessi, DR, Holmes, AB, Downes, CP, James, SR	Biochem J	1996
11598301	Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane Kaech, S, Maira, SM, Brazil, DP, Galetic, I, Ingley, E, Thelen, M, Hemmings, BA	Science	2001
9445477	Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B Gaffney, PR, Painter, GF, Stephens, L, McCormick, F, Hawkins, PT, Anderson, K, Reese, CB, Holmes, AB, Coadwell, J, Stokoe, D, Tempst, P, Erdjument-Bromage, H	Science	1998
9679957	AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells Testa, JR, Cheng, JQ, Jove, R, Liu, AX, Nicosia, SV, Hamilton, TC	Cancer Res.	1998