AKT2 binds PIP3

Stable Identifier
R-HSA-109700
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
PKB attachment to plasma membrane
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The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).

Literature References
PubMed ID Title Journal Year
8645147 Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

James, SR, Downes, CP, Gigg, R, Grove, SJ, Holmes, AB, Alessi, DR

Biochem J 1996
12791994 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

Du, K, Herzig, S, Kulkarni, RN, Montminy, M

Science 2003
11598301 Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

Maira, SM, Galetic, I, Brazil, DP, Kaech, S, Ingley, E, Thelen, M, Hemmings, BA

Science 2001
9445477 Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

Stephens, L, Anderson, K, Stokoe, D, Erdjument-Bromage, H, Painter, GF, Holmes, AB, Gaffney, PR, Reese, CB, McCormick, F, Tempst, P, Coadwell, J, Hawkins, PT

Science 1998
9679957 AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells

Liu, AX, Testa, JR, Hamilton, TC, Jove, R, Nicosia, SV, Cheng, JQ

Cancer Res. 1998
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