Reactome | AKT2 binds PIP3

Schema > Reaction > Entries

AKT2 binds PIP3 Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10661761
displayName	AKT2 binds PIP3
eventOf	[Pathway:R-DME-165158] Activation of AKT2 - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-109702] PDPK1 phosphorylates AKT2 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-109700] AKT2 binds PIP3 - Homo sapiens
input	[Complex:R-DME-162401] AKT2:THEM4,TRIB3 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
name	AKT2 binds PIP3 PKB attachment to plasma membrane
output	[Complex:R-DME-109696] AKT2:PIP3 [plasma membrane] [EntityWithAccessionedSequence:R-DME-162411] trbl [cytosol]
precedingEvent	[Reaction:R-DME-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-109700
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-165158] Activation of AKT2
(precedingEvent)	[Reaction:R-DME-109702] PDPK1 phosphorylates AKT2
(inferredTo)	[Reaction:R-HSA-109700] AKT2 binds PIP3