Reactome | (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]

Schema > Reaction > Entries

(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] Show undefined attributes

catalystActivity	[CatalystActivity:109365] 5'-nucleotidase activity of NT5C1A tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643499] 5'-nucleotidase activity of NT5C1A tetramer [cytosol] Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109356] D'Eustachio, P, 2004-01-06 13:35:00
crossReference	[DatabaseIdentifier:9976334] RHEA:29376 [DatabaseIdentifier:9976341] RHEA:29372 [DatabaseIdentifier:9976355] RHEA:27715 [DatabaseIdentifier:9976336] RHEA:29380 [DatabaseIdentifier:9976361] RHEA:27719 [DatabaseIdentifier:9976350] RHEA:29384
dbId	109387
deleted	[Deleted:500126] Deletion of instances: 109400, 109398, 109393, 109391, 109389 [Deleted:500350] Deletion of instance: 109368
displayName	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
eventOf	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
input	[DefinedSet:R-ALL-500125] (d)AMP, (d)GMP, (d)IMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:109306] Mammalian 5'-nucleotidases [LiteratureReference:109358] Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance [LiteratureReference:109372] The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I [LiteratureReference:109364] Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] AMP + H2O => adenosine + phosphate dAMP + H2O => 2'-deoxyadenosine + phosphate GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
orthologousEvent	[Reaction:R-GGA-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Gallus gallus [Reaction:R-XTR-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Xenopus tropicalis [Reaction:R-DRE-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Danio rerio [Reaction:R-SSC-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Sus scrofa [Reaction:R-BTA-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Bos taurus [Reaction:R-CFA-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Canis familiaris [Reaction:R-RNO-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Rattus norvegicus [Reaction:R-MMU-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Mus musculus
output	[DefinedSet:R-ALL-500124] (d)A, (d)G, (d)I [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[PositiveRegulation:R-HSA-109388] Positive regulation by 'ADP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109387
summation	[Summation:178270] Cytosolic 5'-nucleotidase IA catalyzes the hydrolysis of pur...
updateTrackers	[UpdateTracker:9791070] Update Tracker - [Reaction:109387] (d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791070] Update Tracker - [Reaction:109387] (d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(replacementInstances)	[Deleted:500350] Deletion of instance: 109368 [Deleted:500126] Deletion of instances: 109400, 109398, 109393, 109391, 109389
(hasEvent)	[Pathway:R-HSA-74259] Purine catabolism

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