Reactome | (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]

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(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] Show undefined attributes

catalystActivity	[CatalystActivity:10233028] 5'-nucleotidase activity of NT5C1A tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10233032
displayName	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
eventOf	[Pathway:R-CFA-74259] Purine catabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Homo sapiens
input	[DefinedSet:R-ALL-500125] (d)AMP, (d)GMP, (d)IMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] AMP + H2O => adenosine + phosphate dAMP + H2O => 2'-deoxyadenosine + phosphate GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
output	[DefinedSet:R-ALL-500124] (d)A, (d)G, (d)I [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[PositiveRegulation:R-HSA-109388] Positive regulation by 'ADP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-109387
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-74259] Purine catabolism
(inferredTo)	[Reaction:R-HSA-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]

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