Reactome | IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

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IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) Show undefined attributes

authored	[InstanceEdit:1164950] Ray, K, 2010-12-13
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1067679] Jupe, S, 2010-11-26
dbId	1067651
displayName	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
edited	[InstanceEdit:1112767] Jupe, S, 2010-12-10
eventOf	[Pathway:R-HSA-1059683] Interleukin-6 signaling - Homo sapiens [Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens
followingEvent	[Reaction:R-HSA-1067659] Assembly of hexameric IL-6 receptor - Homo sapiens
input	[Complex:R-HSA-1067687] IL6:IL6R-2 [extracellular region] [Complex:R-HSA-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449998] Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 [LiteratureReference:1164954] Molecular cloning and expression of an IL-6 signal transducer, gp130
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) IL6:sIL6R binds to JAKs:IL6RB (gp130)
orthologousEvent	[Reaction:R-GGA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Gallus gallus [Reaction:R-XTR-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Xenopus tropicalis [Reaction:R-DRE-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Danio rerio [Reaction:R-SSC-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Sus scrofa [Reaction:R-BTA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Bos taurus [Reaction:R-CFA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Canis familiaris [Reaction:R-RNO-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Rattus norvegicus [Reaction:R-MMU-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Mus musculus
output	[Complex:R-HSA-1067691] IL6:sIL6R:IL6RB:JAKs [plasma membrane]
precedingEvent	[Reaction:R-HSA-1067640] IL6 binds IL6R-2 - Homo sapiens [Reaction:R-HSA-1067646] JAK1,JAK2,(TYK2) bind IL6ST - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1164957] Negative regulation by 'IL6:IL6R-2:IL6ST-2 [extracellular region]'
releaseDate	2011-03-15
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1214159] Rose-John, S, 2011-02-11 [InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1067651
summation	[Summation:1067684] The complex of interleukin-6 (IL6) and the soluble, short fo...
updateTrackers	[UpdateTracker:9781986] Update Tracker - [Reaction:1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - v60:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781986] Update Tracker - [Reaction:1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - v60:[modifyText]
(hasEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-HSA-1059683] Interleukin-6 signaling
(precedingEvent)	[Reaction:R-HSA-1067659] Assembly of hexameric IL-6 receptor