Reactome | IL6 binds IL6R-2

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IL6 binds IL6R-2 Show undefined attributes

authored	[InstanceEdit:1164950] Ray, K, 2010-12-13
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1067679] Jupe, S, 2010-11-26
dbId	1067640
displayName	IL6 binds IL6R-2
edited	[InstanceEdit:1112767] Jupe, S, 2010-12-10
eventOf	[Pathway:R-HSA-1059683] Interleukin-6 signaling - Homo sapiens [Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens
followingEvent	[Reaction:R-HSA-1067676] IL6:IL6R-2 binds IL6ST-2 - Homo sapiens [Reaction:R-HSA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-447100] IL6 [extracellular region] [EntityWithAccessionedSequence:R-HSA-1067661] IL6R-2 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449998] Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IL6 binds IL6R-2 Interleukin-6 binds soluble IL6 receptor
orthologousEvent	[Reaction:R-GGA-1067640] IL6 binds IL6R-2 - Gallus gallus [Reaction:R-XTR-1067640] IL6 binds IL6R-2 - Xenopus tropicalis [Reaction:R-DRE-1067640] IL6 binds IL6R-2 - Danio rerio [Reaction:R-SSC-1067640] IL6 binds IL6R-2 - Sus scrofa [Reaction:R-BTA-1067640] IL6 binds IL6R-2 - Bos taurus [Reaction:R-CFA-1067640] IL6 binds IL6R-2 - Canis familiaris [Reaction:R-RNO-1067640] IL6 binds IL6R-2 - Rattus norvegicus [Reaction:R-MMU-1067640] IL6 binds IL6R-2 - Mus musculus
output	[Complex:R-HSA-1067687] IL6:IL6R-2 [extracellular region]
releaseDate	2011-03-15
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1214159] Rose-John, S, 2011-02-11 [InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1067640
summation	[Summation:1067671] The short, soluble form of Interleukin-6 receptor ? (IL6R-2,...
updateTrackers	[UpdateTracker:9984621] Update Tracker - [Reaction:1067640] IL6 binds IL6R-2 - v96:[modifyText] [UpdateTracker:9781717] Update Tracker - [Reaction:1067640] IL6 binds IL6R-2 - v60:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984621] Update Tracker - [Reaction:1067640] IL6 binds IL6R-2 - v96:[modifyText] [UpdateTracker:9781717] Update Tracker - [Reaction:1067640] IL6 binds IL6R-2 - v60:[modifyText]
(hasEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-HSA-1059683] Interleukin-6 signaling
(precedingEvent)	[Reaction:R-HSA-1067676] IL6:IL6R-2 binds IL6ST-2 [Reaction:R-HSA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)