Reactome | Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol

Schema > BlackBoxEvent > Entries

Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:927893] endoplasmic reticulum quality control compartment
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10593004
displayName	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol
eventOf	[Pathway:R-DRE-901032] ER Quality Control Compartment (ERQC) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Danio rerio [Reaction:R-DRE-8853379] ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) - Danio rerio
inferredFrom	[BlackBoxEvent:R-HSA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Homo sapiens
input	[Complex:R-DRE-8867287] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment]
isInDisease	false
isInferred	true
maxDepth	1
name	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol Glycoproteins with major folding defects are sent to degradation by OS9:SEL1:SYVN1 dimer:DERL2
output	[Complex:R-DRE-8866894] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68323] Danio rerio
stId	R-DRE-1022127
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-901032] ER Quality Control Compartment (ERQC)
(precedingEvent)	[Reaction:R-DRE-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins [Reaction:R-DRE-8853379] ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)
(inferredTo)	[BlackBoxEvent:R-HSA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol

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