Reactome | Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins

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Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins Show undefined attributes

authored	[InstanceEdit:8850593] Jassal, Bijay, 2015-12-24
catalystActivity	[CatalystActivity:8850595] peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity of Deglycosylation complex [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8850593] Jassal, Bijay, 2015-12-24
dbId	8850594
displayName	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
edited	[InstanceEdit:8850593] Jassal, Bijay, 2015-12-24
eventOf	[Pathway:R-HSA-532668] N-glycan trimming in the ER and Calnexin/Calreticulin cycle - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-8866894] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8852863] The cytoplasmic peptide:N-glycanase (NGLY1) - Structure, expression and cellular functions [LiteratureReference:8852864] A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins [LiteratureReference:8852856] Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase [LiteratureReference:8852862] A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs [LiteratureReference:8852855] A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol [LiteratureReference:8852868] The retrotranslocation protein Derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
orthologousEvent	[Reaction:R-CEL-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Caenorhabditis elegans [Reaction:R-DME-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Drosophila melanogaster [Reaction:R-GGA-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Gallus gallus [Reaction:R-XTR-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Xenopus tropicalis [Reaction:R-DRE-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Danio rerio [Reaction:R-SSC-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Sus scrofa [Reaction:R-BTA-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Bos taurus [Reaction:R-CFA-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Canis familiaris [Reaction:R-RNO-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Rattus norvegicus [Reaction:R-MMU-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Mus musculus
output	[DefinedSet:R-ALL-8852852] (GlcNAc)2 (Man)9-5 [cytosol] [OtherEntity:R-ALL-1022114] unfolded protein [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8850594
summation	[Summation:8852857] Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase ...

Referrals

(hasEvent)

[Pathway:R-HSA-532668] N-glycan trimming in the ER and Calnexin/Calreticulin cycle

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