Reactome | Factor H binds host cell surface markers

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Factor H binds host cell surface markers Show undefined attributes

authored	[InstanceEdit:998152] Jupe, S, 2010-11-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1006170] Jupe, S, 2010-11-10
dbId	1006169
displayName	Factor H binds host cell surface markers
edited	[InstanceEdit:998152] Jupe, S, 2010-11-09
eventOf	[Pathway:R-HSA-977606] Regulation of Complement cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-981728] Factor H binds to membrane-associated C3b - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-976788] CFH [extracellular region] [Complex:R-ALL-1006146] Host cell surface [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1006145] Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Factor H binds host cell surface markers
orthologousEvent	[Reaction:R-GGA-2132283] Factor H binds to host cell surface - Gallus gallus [Reaction:R-GGA-1006169] Factor H binds host cell surface markers - Gallus gallus [Reaction:R-XTR-1006169] Factor H binds host cell surface markers - Xenopus tropicalis [Reaction:R-DRE-1006169] Factor H binds host cell surface markers - Danio rerio [Reaction:R-SSC-1006169] Factor H binds host cell surface markers - Sus scrofa [Reaction:R-BTA-1006169] Factor H binds host cell surface markers - Bos taurus [Reaction:R-CFA-1006169] Factor H binds host cell surface markers - Canis familiaris [Reaction:R-RNO-1006169] Factor H binds host cell surface markers - Rattus norvegicus [Reaction:R-MMU-1006169] Factor H binds host cell surface markers - Mus musculus
output	[Complex:R-HSA-1006173] CFH:Host cell surface [plasma membrane]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2109568] Bradley, DT, 2012-02-13 [InstanceEdit:2109566] Fraczek, LA, 2012-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1006169
summation	[Summation:1006148] Factor H (CFH) preferentially binds to host cells and surfac...
updateTrackers	[UpdateTracker:9783528] Update Tracker - [Reaction:1006169] Factor H binds host cell surface markers - v56:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783528] Update Tracker - [Reaction:1006169] Factor H binds host cell surface markers - v56:[modifyText]
(hasEvent)	[Pathway:R-HSA-977606] Regulation of Complement cascade
(precedingEvent)	[Reaction:R-HSA-981728] Factor H binds to membrane-associated C3b