Factor H binds host cell surface markers

Stable Identifier
R-HSA-1006169
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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Factor H binds host cell surface markers
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Factor H (CFH) preferentially binds to host cells and surfaces that have negatively charged cell surface polyanions such as heparin and sialic acid commonly found on host cells (Kazatchkine et al. 1979, Meri & Pangburn 1990). This mediates protection of plasma-exposed host structures.

Literature References
PubMed ID Title Journal Year
16192651 Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site

Jokiranta, TS, Cheng, ZZ, Seeberger, H, Jòzsi, M, Heinen, S, Noris, M, Remuzzi, G, Ormsby, R, Gordon, DL, Meri, S, Hellwage, J, Zipfel, PF

Am J Pathol 2005
Participants
Input
Output
Participant Of
hasEvent
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Authored
Jupe, S  (2010-11-09)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2010-11-10)