Factor H binds host cell surface markers

Stable Identifier
R-HSA-1006169
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Factor H binds host cell surface markers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Factor H (CFH) preferentially binds to host cells and surfaces that have negatively charged cell surface polyanions such as heparin and sialic acid commonly found on host cells (Kazatchkine et al. 1979, Meri & Pangburn 1990). This mediates protection of plasma-exposed host structures.

Literature References
PubMed ID Title Journal Year
16192651 Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site

Remuzzi, G, Jòzsi, M, Seeberger, H, Gordon, DL, Noris, M, Cheng, ZZ, Jokiranta, TS, Heinen, S, Hellwage, J, Meri, S, Zipfel, PF, Ormsby, R

Am J Pathol 2005
Participants
Input
Output
Participates
as an event of
Orthologous Events
Factor H binds host cell surface markers (Bos taurus)
Factor H binds host cell surface markers (Canis familiaris)
Factor H binds host cell surface markers (Danio rerio)
Factor H binds host cell surface markers (Gallus gallus)
Factor H binds host cell surface markers (Mus musculus)
Factor H binds host cell surface markers (Rattus norvegicus)
Factor H binds host cell surface markers (Sus scrofa)
Factor H binds host cell surface markers (Xenopus tropicalis)
Factor H binds to host cell surface (Gallus gallus)
Authored
Jupe, S  (2010-11-09)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2010-11-10)
Cite Us!