Reactome | Factor H binds host cell surface markers

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Factor H binds host cell surface markers Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10680486
displayName	Factor H binds host cell surface markers
eventOf	[Pathway:R-XTR-977606] Regulation of Complement cascade - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-981728] Factor H binds to membrane-associated C3b - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-1006169] Factor H binds host cell surface markers - Homo sapiens
input	[DefinedSet:R-XTR-976788-3] Homologues of CFH [extracellular region] [Complex:R-ALL-1006146] Host cell surface [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Factor H binds host cell surface markers
output	[Complex:R-XTR-1006173] CFH:Host cell surface [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1006169
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-977606] Regulation of Complement cascade
(precedingEvent)	[Reaction:R-XTR-981728] Factor H binds to membrane-associated C3b
(inferredTo)	[Reaction:R-HSA-1006169] Factor H binds host cell surface markers

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