Reactome | Factor H binds to host cell surface

Schema > Reaction > Entries

authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132292] Shamovsky, V, 2012-02-21
dbId	2132283
displayName	Factor H binds to host cell surface
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
eventOf	[Pathway:R-GGA-2132281] Regulation of complement cascades - Gallus gallus
inferredFrom	[Reaction:R-HSA-1006169] Factor H binds host cell surface markers - Homo sapiens
input	[OtherEntity:R-ALL-2132109] Cell-surface carbohydrates [plasma membrane] [EntityWithAccessionedSequence:R-GGA-2132241] CFH [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2314669] Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement [LiteratureReference:2314640] A new map of glycosaminoglycan and C3b binding sites on factor H
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Factor H binds to host cell surface
output	[Complex:R-GGA-2132252] CHF [plasma membrane]
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2132283
summation	[Summation:2859039] In mammals, extracellular factor H binds negatively-charged ...

(hasEvent)	[Pathway:R-GGA-2132281] Regulation of complement cascades
(inferredTo)	[Reaction:R-HSA-1006169] Factor H binds host cell surface markers

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